# Ecology: Gene-Drive Suppression A genotype-tracking gene-drive model for mosquito population suppression. **Release transgenic males carrying a Y-linked editor, an X-shredder, and an autosomal homing construct, then watch the wild population collapse through sex-ratio distortion and genetic load.** ## What it simulates - 1071 genotypes tracked across three genetic components (Y editor, X shredder, autosomal homing). - Each generation applies mutation, homing, editing, recombination, gamete production with X-shredding, zygote formation, Beverton–Holt density-dependent survival, and genotype-specific fitness selection. - The default scenario uses high efficiencies and zero resistance, so the population collapses within tens of generations.  ## Run it on the Hub 1. Open the [Geci2022 Gene-Drive Suppression Lab](https://hub.biosimulant.com/labs/9955f7cf-d553-4e60-84ef-995ef5780d64) on the public Hub. 2. Click **Run**. The default scenario runs for 100 generations. ## Inputs you can tune The lab exposes 24 input ports. The most consequential ones: | Input | Meaning | |---|---| | `release_size` | Transgenic release as a fraction of the initial population (default 0.1). | | `homing_efficiency` | Homing efficiency at the autosomal cut site. | | `editing_efficiency` | Female-target editing efficiency. | | `shredding_efficiency` | X-shredding efficiency in male gametes. | | `homing_resistance_rate` | Autosomal r3 resistance generation rate. | | `editing_resistance_rate` | Editing resistance rate. | | `shredding_resistance_rate` | Shredding resistance rate. | | `net_reproduction_rate` | Net reproduction rate (default 6.0). | | `juvenile_survival` | Juvenile survival probability. | Resistance rates and per-component fitness costs let you stress-test the drive against realistic counter-pressures. ## What results to expect - **Adult population time series**: total adults, females, and males. The default scenario peaks around generation 5 then collapses to near zero by generation 50. - **Drive metrics**: drive frequency, resistance frequency, male fraction, and suppression ratio. - **Summary table**: initial and final population sizes, peak drive and resistance frequencies, and the final suppression ratio.  ## Reference Faithful Python port of the upstream Julia model from Geci et al. (2022), [BioModels MODEL2301120001](https://www.ebi.ac.uk/biomodels/MODEL2301120001). **Info:** Source on GitHub: [models-ecology — geci2022-gene-drive-suppression](https://github.com/Biosimulant/models-ecology/tree/main/labs/ecology-geci2022-gene-drive-suppression).